Opportunity Information: Apply for RFA CA 18 003
The Advanced Development and Validation of Emerging Molecular and Cellular Analysis Technologies for Basic and Clinical Cancer Research funding opportunity (RFA-CA-18-003) is a National Cancer Institute (NCI) grant solicitation under the broader Innovative Molecular Analysis Technologies (IMAT) Program. It supports exploratory projects that push forward new or recently invented molecular and cellular analysis technologies that can change what researchers are able to measure, see, or interpret in cancer biology. The emphasis is not on asking a new biological question with familiar tools, but on improving the tools themselves so they can be reliably used by many labs and ultimately accelerate progress across cancer research and, downstream, clinical translation. Clinical trials are not allowed under this mechanism.
This FOA uses the R33 funding mechanism, which is meant for projects that are past the earliest proof-of-concept stage. Applicants are expected to show supportive preliminary data indicating that the biggest feasibility hurdles have already been addressed. At the same time, the technology still needs additional development and, most importantly, rigorous validation before the wider research community is likely to adopt it. In practical terms, NCI is looking for technologies that are promising and demonstrably workable, but not yet mature enough in performance, robustness, reproducibility, or usability to be considered ready for broad dissemination.
Projects must focus on technologies that provide novel capabilities for targeting, probing, or assessing molecular and cellular features relevant to cancer. The most competitive proposals are those that clearly improve cancer-related characterization at the molecular and/or cellular level, such as enabling new kinds of measurements, higher-resolution profiling, better sensitivity or specificity, improved throughput, reduced sample requirements, or more informative readouts from complex tissues. Importantly, the proposed technology can be broadly applicable across cancers or research contexts, but the core development work must be anchored in improving how cancer is molecularly or cellularly analyzed.
The solicitation highlights a wide range of potential impact areas, including basic cancer biology, early detection and screening, clinical diagnosis, treatment and therapeutic monitoring, cancer control, epidemiology, and research addressing cancer health disparities. That means a technology could be positioned to help discover mechanisms, identify biomarkers, stratify patients, characterize tumor heterogeneity, analyze the tumor microenvironment, support population-oriented measurements, or improve the quality and reach of cancer research in underserved settings. The common thread is that the technology should plausibly accelerate research or improve the quality of evidence by enabling better molecular and cellular characterization than is currently possible.
A key boundary condition is responsiveness: proposals that mainly apply an already established technology to a new disease subtype, target, or clinical question are explicitly non-responsive and will not be reviewed. In other words, novelty must live in the technology or methodology development itself, not primarily in the biological application. Reviewers are looking for real advancement in the platform, assay, computational method, instrumentation, workflow, or validation framework that meaningfully changes performance or capability relative to what is available.
From an administrative standpoint, this is a discretionary grant from the U.S. Department of Health and Human Services (NIH/NCI), listed under CFDA 93.394. The opportunity was created November 20, 2017, with an original closing date of September 28, 2018. The award ceiling is $300,000, and the agency anticipated making around 10 awards. Eligibility is broad and includes various levels of government, public and private institutions of higher education, nonprofit organizations (with or without 501(c)(3) status), for-profit organizations (other than small businesses), small businesses, tribal governments and tribal organizations, and other entities as described in the additional eligibility language.
Overall, the program is designed to bridge the gap between a promising, partially demonstrated technology and a validated, adoptable tool that the cancer research community can trust and use. The ideal outcome is a well-developed and carefully validated molecular or cellular analysis technology that delivers new capabilities or markedly improved performance, with evidence strong enough to support wider uptake and, eventually, meaningful impact across the cancer research pipeline.Apply for RFA CA 18 003
- The Department of Health and Human Services, National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Advanced Development and Validation of Emerging Molecular and Cellular Analysis Technologies for Basic and Clinical Cancer Research (R33 - Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.394.
- This funding opportunity was created on Nov 20, 2017.
- Applicants must submit their applications by Sep 28, 2018. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $300,000.00 in funding.
- The number of recipients for this funding is limited to 10 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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| Funding Opportunity |
|---|
| Innovative Biospecimen Science Technologies for Basic and Clinical Cancer Research (R21 - Clinical Trial Not Allowed) Apply for RFA CA 18 004 Funding Number: RFA CA 18 004 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Advanced Development and Validation of Emerging Biospecimen Science Technologies for Basic and Clinical Cancer Research (R33 - Clinical Trial Not Allowed) Apply for RFA CA 18 005 Funding Number: RFA CA 18 005 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $300,000 |
| Fast-Track Development of Medications to Treat Cannabis Use Disorders (UG3/UH3 Clinical Trial Optional) Apply for PAR 18 221 Funding Number: PAR 18 221 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $1,000,000 |
| Revisions for Incorporation of Novel NCI-Supported Technology to Accelerate Cancer Research (P01 Clinical Trials Optional) Apply for RFA CA 18 009 Funding Number: RFA CA 18 009 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $150,000 |
| Revisions for Incorporation of Novel NCI-Supported Technology to Accelerate Cancer Research (P50 Clinical Trials Optional) Apply for RFA CA 18 010 Funding Number: RFA CA 18 010 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $150,000 |
| Revisions for Incorporation of Novel NCI-Supported Technology to Accelerate Cancer Research (U54 Clinical Trials Optional) Apply for RFA CA 18 008 Funding Number: RFA CA 18 008 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $150,000 |
| Revisions for Incorporation of Novel NCI-Supported Technology to Accelerate Cancer Research (U01 Clinical Trials Optional) Apply for RFA CA 18 007 Funding Number: RFA CA 18 007 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $150,000 |
| Revisions for Incorporation of Novel NCI-Supported Technology to Accelerate Cancer Research (R01 Clinical Trials Optional) Apply for RFA CA 18 006 Funding Number: RFA CA 18 006 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $150,000 |
| NIDA Translational Avant-Garde Award for Development of Medication to Treat Substance Use Disorders (UG3/UH3, Clinical Trial Optional) Apply for RFA DA 18 020 Funding Number: RFA DA 18 020 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $1,000,000 |
| Administrative Supplements to NCI Grant and Cooperative Agreement Awards to Support Collaborations with the PDX Development and Trial Centers Research Network (PDXNet)(Admin Suppl - Clinical Trial Not Allowed) Apply for PA 18 496 Funding Number: PA 18 496 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $125,000 |
| Identification of Biomarkers of HIV-1 Pathogenesis and Substance Abuse Comorbidity (R01- Clinical Trial Not Allowed) Apply for RFA DA 18 023 Funding Number: RFA DA 18 023 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Distance Learning and Telemedicine Grant Program Apply for RUS 18 01 DLT Funding Number: RUS 18 01 DLT Agency: Department of Agriculture, Utilities Programs Category: Education, Health Funding Amount: $500,000 |
| Administrative Supplements to NCI Grant and Cooperative Agreement Awards to Support Collaborations with the Drug Resistance and Sensitivity Network (DRSN)(Admin Supp Clinical Trial Not Allowed) Apply for PAR 18 752 Funding Number: PAR 18 752 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $250,000 |
| NCI Community Oncology Research Program (NCORP) Community Sites (UG1 Clinical Trial Required) Apply for RFA CA 18 016 Funding Number: RFA CA 18 016 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| NCI Community Oncology Research Program (NCORP) Minority/Underserved Community Sites (UG1 Clinical Trial Required) Apply for RFA CA 18 017 Funding Number: RFA CA 18 017 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| NCI Community Oncology Research Program (NCORP) Research Bases (UG1 Clinical Trial Required) Apply for RFA CA 18 015 Funding Number: RFA CA 18 015 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Approaches to Identify and Care for Individuals with Inherited Cancer Syndromes (U01 Clinical Trial Required) Apply for RFA CA 19 017 Funding Number: RFA CA 19 017 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| HIV/AIDS High Priority Drug Abuse Research (R01 Clinical Trial Optional) Apply for PAS 18 915 Funding Number: PAS 18 915 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Fusion Oncoproteins in Childhood Cancers (FusOnC2) Consortium (U54 Clinical Trial Not Allowed) Apply for RFA CA 19 016 Funding Number: RFA CA 19 016 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $1,600,000 |
| Administrative Supplements to Cancer Center Support Grants to Strengthen the Research, Training, and Outreach Capacity of the Geographic Management of Cancer Health Disparities Program (Admin Suppl - Clinical Trial Not Allowed) Apply for PA 18 934 Funding Number: PA 18 934 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $250,000 |
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