Opportunity Information: Apply for RFA DA 20 022
Assessing the Effects of Cannabinoids on HIV-Induced Inflammation (R01 Clinical Trial Optional) is a National Institutes of Health (NIH) discretionary grant opportunity (Funding Opportunity Number RFA-DA-20-022; CFDA 93.279) that supports research aimed at clarifying how cannabinoids and the endocannabinoid system influence long-lasting inflammation associated with HIV, and how that inflammation, in turn, affects nervous system function. The emphasis is on understanding biological mechanisms rather than simply documenting outcomes, with a focus on basic science and preclinical work that can explain cause-and-effect relationships. Although the mechanism is an R01 and the announcement notes "Clinical Trial Optional," the core intent is to stimulate mechanistic research that can lay the groundwork for future translational or clinical directions.
The scientific problem driving the announcement is HIV-associated persistent inflammation, which can remain even when viral replication is controlled and can contribute to neurological and other systemic complications. This FOA specifically invites studies that probe the interaction between HIV-related inflammatory pathways and cannabinoid signaling, including endogenous cannabinoid pathways (the endocannabinoid system). Applicants are expected to examine how cannabinoids (which may include phytocannabinoids, synthetic cannabinoids, or modulators of endocannabinoid signaling, depending on the proposed model) alter inflammatory processes relevant to HIV and to investigate downstream consequences for nervous system function. In practice, this could involve cellular and molecular studies, animal models, neuroimmune or glial mechanisms, immune signaling and cytokine pathways, or other mechanistic approaches that help explain how cannabinoid-related signaling intersects with HIV-driven inflammation and neurobiological outcomes.
A key structural requirement is that proposed projects must bring together expertise and resources spanning both HIV/AIDS research and addiction science. This means applications are expected to be genuinely interdisciplinary, not simply adjacent, with teams positioned to address cannabinoid biology in a way that is credible to addiction science and simultaneously grounded in HIV pathogenesis and HIV-related inflammation. The intent is to ensure that the work is scientifically rigorous regarding both the pharmacology and biology of cannabinoids and the specific immunological and neurological issues that arise in the context of HIV.
Eligibility is broad and includes many types of domestic and non-domestic organizations. Eligible applicants include state, county, and local governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; Native American tribal organizations (other than federally recognized tribal governments); public housing authorities/Indian housing authorities; nonprofit organizations with or without 501(c)(3) status (other than institutions of higher education); for-profit organizations (other than small businesses); and small businesses. The FOA also explicitly calls out additional eligible applicant categories such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible agencies of the federal government, regional organizations, U.S. territories or possessions, and foreign (non-U.S.) entities.
From an administrative standpoint, this opportunity was published by NIH with a creation date of November 7, 2019, and an original closing date of March 11, 2020. The funding instrument is a grant, using the R01 activity code, and it falls under the education and health activity category in the source listing. The provided listing does not specify an award ceiling or expected number of awards, indicating that those details were either not included in the excerpt or were not set in the source record.
Overall, the grant is best understood as a targeted NIH request for mechanistic studies that explain how cannabinoid-related pathways may shape HIV-associated chronic inflammation and the neurological consequences of that inflammation, with a strong expectation of cross-cutting expertise in HIV/AIDS and addiction science and a wide set of eligible institutional applicants, including underserved-serving institutions, community-based groups, and international organizations.Apply for RFA DA 20 022
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Assessing the Effects of Cannabinoids on HIV-Induced Inflammation (R01 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.279.
- This funding opportunity was created on 2019-11-07.
- Applicants must submit their applications by 2020-03-11. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
What is the name of this grant opportunity?
The opportunity is titled "Assessing the Effects of Cannabinoids on HIV-Induced Inflammation (R01 Clinical Trial Optional)."
Which agency is offering this opportunity?
This is a National Institutes of Health (NIH) discretionary grant opportunity.
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is RFA-DA-20-022.
What is the CFDA number listed for this opportunity?
The CFDA number provided is 93.279.
What type of funding instrument is this?
The funding instrument is a grant.
What activity code/mechanism does this opportunity use?
This opportunity uses the R01 activity code.
Are clinical trials required under this FOA?
No. The announcement is listed as "Clinical Trial Optional," meaning clinical trials are not required based on the information provided.
What is the main purpose or goal of this FOA?
The goal is to support research that clarifies how cannabinoids and the endocannabinoid system influence long-lasting inflammation associated with HIV, and how that inflammation affects nervous system function.
What scientific problem is this FOA trying to address?
The FOA is driven by the problem of HIV-associated persistent inflammation, which can remain even when viral replication is controlled and can contribute to neurological and other systemic complications.
What is the FOA encouraging researchers to study about cannabinoids?
It invites studies that examine interactions between HIV-related inflammatory pathways and cannabinoid signaling, including endogenous cannabinoid pathways (the endocannabinoid system), and how these interactions affect inflammation and nervous system function.
Does the FOA prioritize mechanistic studies or outcomes-focused studies?
The emphasis is on understanding biological mechanisms and cause-and-effect relationships, rather than simply documenting outcomes.
What kinds of research approaches are mentioned as examples?
Examples mentioned include cellular and molecular studies, animal models, neuroimmune or glial mechanisms, immune signaling and cytokine pathways, and other mechanistic approaches relevant to HIV-driven inflammation and neurobiological outcomes.
Which forms of cannabinoids may be relevant under this FOA?
Based on the proposed model, cannabinoids may include phytocannabinoids, synthetic cannabinoids, or modulators of endocannabinoid signaling.
What is meant by the "endocannabinoid system" in the context of this FOA?
The FOA references endogenous cannabinoid pathways, described as the endocannabinoid system, as a key biological signaling system to be studied in relation to HIV-associated inflammation.
How does nervous system function fit into the research scope?
Applicants are expected to investigate how HIV-associated inflammation (and its modulation by cannabinoid-related pathways) affects nervous system function, including downstream neurobiological consequences.
Is the FOA mainly basic science, preclinical, or clinical in focus?
The focus is on basic science and preclinical work that can explain cause-and-effect relationships, while laying groundwork for future translational or clinical directions.
Does this FOA require interdisciplinary expertise?
Yes. A key structural requirement is that projects must bring together expertise and resources spanning both HIV/AIDS research and addiction science.
What does NIH mean by "genuinely interdisciplinary" for this FOA?
Applications are expected to integrate HIV/AIDS research and addiction science in a substantive way, with teams positioned to address cannabinoid biology credibly within addiction science while also being grounded in HIV pathogenesis and HIV-related inflammation.
Who is eligible to apply?
Eligibility is broad and includes many domestic and non-domestic organizations, including governments, higher education institutions, nonprofits, for-profits (other than small businesses), and small businesses.
Are U.S. state, county, and local governments eligible applicants?
Yes. State, county, and local governments are listed as eligible applicants.
Are institutions of higher education eligible to apply?
Yes. Public and state-controlled institutions of higher education and private institutions of higher education are both listed as eligible.
Are nonprofit organizations eligible?
Yes. Nonprofit organizations with or without 501(c)(3) status (other than institutions of higher education) are eligible.
Are for-profit organizations eligible?
Yes. For-profit organizations (other than small businesses) are listed as eligible, and small businesses are also listed as eligible.
Are tribal entities eligible?
Yes. Federally recognized Native American tribal governments and Native American tribal organizations (other than federally recognized tribal governments) are listed as eligible.
Are public housing authorities eligible applicants?
Yes. Public housing authorities/Indian housing authorities are listed as eligible.
Are faith-based or community-based organizations eligible?
Yes. Faith-based or community-based organizations are explicitly called out as eligible applicant categories.
Are U.S. territories or possessions included in eligibility?
Yes. U.S. territories or possessions are included in the list of eligible applicant categories.
Are foreign (non-U.S.) organizations eligible to apply?
Yes. Foreign (non-U.S.) entities are explicitly included as eligible applicants.
Are minority-serving institutions referenced as eligible?
Yes. The FOA explicitly calls out categories including HBCUs, Hispanic-serving Institutions, TCCUs, Alaska Native and Native Hawaiian Serving Institutions, and AANAPISIs.
Are federal government agencies eligible to apply?
Yes. Eligible agencies of the federal government are included among eligible applicant categories.
When was this opportunity created/published?
The creation date provided is November 7, 2019.
What was the original closing date?
The original closing date listed is March 11, 2020.
Is an award ceiling provided in the listing?
No. The provided listing does not specify an award ceiling.
Does the listing state the expected number of awards?
No. The provided listing does not include an expected number of awards.
How is this opportunity categorized in the source listing?
It is listed under the education and health activity category in the source listing.
What is the overall takeaway about what NIH is trying to fund here?
NIH is seeking targeted mechanistic studies explaining how cannabinoid-related pathways shape HIV-associated chronic inflammation and the neurological consequences of that inflammation, with a strong expectation of cross-cutting expertise in HIV/AIDS and addiction science.
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