Opportunity Information: Apply for RFA ES 17 005
The Environmental influences on Placental Origins of Development (ePOD) (R01) funding opportunity (RFA-ES-17-005) is a National Institutes of Health (NIH) research grant initiative designed to push forward multidisciplinary studies on how early-life environmental exposures shape the placenta and, through the placenta, influence health outcomes later in life. The core idea behind the announcement is that the placenta is not just a temporary organ supporting pregnancy, but a key biological interface where chemical, nutritional, psychosocial, and other exposures can alter growth, development, and function in ways that may program disease risk or resilience in the child. Projects supported under this FOA are expected to connect mechanistic biology to human relevance by combining controlled experimental systems (such as animal models and cell-based models) with human-focused approaches that rely on non-invasive placenta-related materials or measures, such as placenta tissues that can be collected without invasive procedures and/or placental biomarkers measurable in accessible human samples.
The scientific scope emphasizes research that links exposures occurring early in life to measurable changes in placental development and performance, and then ties those placental changes to downstream consequences for offspring health. In practice, this encourages applications that can explain "how" an exposure affects placental pathways (for example, vascular development, endocrine signaling, nutrient transport, immune regulation, oxidative stress responses, epigenetic regulation, or barrier function) and also show why those pathways matter for developmental trajectories and later health risks. The FOA is structured to stimulate collaborations across fields that do not always work together, such as environmental health sciences, developmental biology, obstetrics, pediatrics, toxicology, epidemiology, genomics/epigenomics, bioinformatics, and biomarker science, with the expectation that integrating these perspectives will yield more credible and actionable insights than any single approach alone.
This opportunity uses the NIH R01 mechanism, which typically supports substantial, hypothesis-driven research programs. The announcement lists an award ceiling of $400,000 (as provided in the source data) and indicates the program anticipated making awards, although the expected number of awards is not specified in the provided excerpt. The opportunity falls under the broad activity category of Environment and Health and is associated with CFDA number 93.113. The original closing date in the source information is June 30, 2017, and the creation date is February 15, 2017, which places it in a specific historical funding cycle; anyone looking to pursue similar work now would generally use this as a reference point and then check for newer or reissued NIH/NIEHS funding opportunities with comparable aims.
Eligibility is broad and includes many types of U.S.-based organizations and governmental entities. Eligible applicants listed include state, county, city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; Native American tribal governments (federally recognized); tribal organizations that are not federally recognized; public housing authorities/Indian housing authorities; nonprofits with and without 501(c)(3) status (excluding institutions of higher education as specified in the listing); for-profit organizations other than small businesses; and small businesses. The FOA also highlights additional eligible applicant categories such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, regional organizations, eligible federal agencies, and U.S. territories or possessions. On the other hand, non-domestic (non-U.S.) entities (foreign organizations and foreign institutions) are stated as not eligible to apply, and non-domestic components of U.S. organizations are also not eligible to apply. At the same time, the FOA allows "foreign components" as defined by the NIH Grants Policy Statement, meaning a U.S. applicant organization may be able to include certain types of substantive project elements performed outside the U.S. if they meet NIH’s definition and requirements for foreign components.
Overall, the ePOD (R01) announcement is aimed at building a stronger, mechanistically grounded understanding of the placenta as a central mediator between environmental exposures and child health, and it encourages research designs that intentionally bridge laboratory models with human-relevant, non-invasive placenta tissue resources or biomarker-based evidence. This combination is meant to improve causal inference, clarify biological pathways, and ultimately support better prevention strategies, risk assessment, or intervention targets related to prenatal and early developmental exposures.Apply for RFA ES 17 005
- The National Institutes of Health in the environment, health sector is offering a public funding opportunity titled "Environmental influences on Placental Origins of Development (ePOD) (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113.
- This funding opportunity was created on 2017-02-15.
- Applicants must submit their applications by 2017-06-30. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $400,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs): Environmental influences on Placental Origins of Development (ePOD) (R01) - RFA-ES-17-005
What is the ePOD (R01) funding opportunity?
The Environmental influences on Placental Origins of Development (ePOD) (R01) funding opportunity (RFA-ES-17-005) is an NIH research grant initiative that supports multidisciplinary studies on how early-life environmental exposures affect the placenta and, through the placenta, influence health outcomes later in life.
What is the main scientific idea behind this opportunity?
The central idea is that the placenta is a key biological interface during pregnancy. Environmental exposures (chemical, nutritional, psychosocial, and others) can alter placental growth, development, and function in ways that may shape disease risk or resilience in the child later in life.
What kinds of environmental exposures are within scope?
The opportunity describes early-life exposures broadly, including chemical, nutritional, psychosocial, and other exposures that could influence placental development and function.
What types of studies are encouraged?
Projects are expected to connect mechanistic biology to human relevance by combining controlled experimental systems (such as animal models and cell-based models) with human-focused approaches that use non-invasive placenta-related materials or measures.
Does the FOA require both experimental models and human-relevant work?
The FOA emphasizes combining controlled experimental systems (for example, animal and cell-based models) with human-focused approaches using non-invasive placenta-related materials or biomarkers in accessible human samples, indicating an expectation to intentionally bridge mechanistic and human relevance.
What does "non-invasive placenta-related materials or measures" mean in this context?
Examples given include placenta tissues that can be collected without invasive procedures and/or placental biomarkers that can be measured in accessible human samples.
What kinds of biological pathways or placental functions might applications examine?
The FOA provides examples of relevant placental pathways and functions, such as vascular development, endocrine signaling, nutrient transport, immune regulation, oxidative stress responses, epigenetic regulation, and barrier function.
What is meant by linking exposures to downstream consequences for offspring health?
The scientific scope emphasizes connecting early-life exposures to measurable changes in placental development and performance, and then tying those placental changes to later consequences for offspring health outcomes.
Why does this opportunity stress multidisciplinary collaboration?
The FOA is structured to stimulate collaborations across fields that do not always work together, with the expectation that integrating these perspectives will produce more credible and actionable insights than any single approach alone.
Which research disciplines are specifically mentioned as relevant?
The FOA highlights integration across areas such as environmental health sciences, developmental biology, obstetrics, pediatrics, toxicology, epidemiology, genomics/epigenomics, bioinformatics, and biomarker science.
What grant mechanism is used for this opportunity?
This opportunity uses the NIH R01 mechanism, which typically supports substantial, hypothesis-driven research programs.
What is the award ceiling for this opportunity?
The announcement lists an award ceiling of $400,000 (as provided in the source information).
How many awards were expected to be made?
The source information indicates that awards were anticipated, but the expected number of awards is not specified in the provided excerpt.
What is the activity category and CFDA number associated with this opportunity?
The opportunity is in the broad activity category of Environment and Health and is associated with CFDA number 93.113.
When was this funding opportunity created and when did it close?
The creation date in the source information is February 15, 2017, and the original closing date is June 30, 2017.
Is this opportunity part of a historical funding cycle?
Yes. Based on the creation and closing dates (2017), it is tied to a specific historical funding cycle. The provided description suggests using it as a reference point and checking for newer or reissued NIH/NIEHS funding opportunities with comparable aims for current submissions.
Who is eligible to apply?
Eligibility is broad and includes many types of U.S.-based organizations and governmental entities, including various government bodies, higher education institutions (public and private), tribal governments and organizations, nonprofits (with and without 501(c)(3) status, as specified), for-profit organizations (other than small businesses), and small businesses.
Which U.S. government entities are eligible?
Eligible governmental applicants listed include state governments; county governments; city or township governments; and special district governments.
Are educational organizations eligible?
Yes. Eligible applicants include independent school districts, public and state-controlled institutions of higher education, and private institutions of higher education. The listing also highlights multiple categories of minority-serving and specialized institutions.
Are tribal governments and tribal organizations eligible?
Yes. Eligible applicants include Native American tribal governments (federally recognized) and tribal organizations that are not federally recognized.
Are nonprofits eligible, and does 501(c)(3) status matter?
The eligibility list includes nonprofits with 501(c)(3) status and nonprofits without 501(c)(3) status, with exclusions/notes as specified in the listing (including a note excluding institutions of higher education as specified in the nonprofit listing).
Are for-profit organizations eligible?
Yes. The eligibility list includes for-profit organizations other than small businesses, and it also explicitly includes small businesses as eligible applicants.
Are public housing authorities eligible?
Yes. Public housing authorities/Indian housing authorities are listed as eligible applicants.
Are U.S. territories or possessions eligible?
Yes. U.S. territories or possessions are highlighted as eligible applicant categories.
Are federal agencies eligible to apply?
Yes. Eligible federal agencies are included in the highlighted eligible applicant categories.
Are faith-based or community-based organizations eligible?
Yes. Faith-based or community-based organizations are specifically highlighted among eligible applicant categories.
Are regional organizations eligible?
Yes. Regional organizations are specifically highlighted among eligible applicant categories.
Are non-U.S. (foreign) organizations eligible to apply directly?
No. The FOA states that non-domestic (non-U.S.) entities (foreign organizations and foreign institutions) are not eligible to apply.
Can a U.S. organization include a non-U.S. component in its application?
The FOA states that non-domestic components of U.S. organizations are not eligible. However, it also allows "foreign components" as defined by the NIH Grants Policy Statement, meaning a U.S. applicant may be able to include certain substantive elements performed outside the U.S. if they meet NIH's definition and requirements for a foreign component.
What is the overall goal of the ePOD (R01) program?
The overall goal is to build a stronger, mechanistically grounded understanding of the placenta as a central mediator between environmental exposures and child health, by supporting studies that bridge laboratory models with human-relevant placenta tissues or biomarker-based evidence.
What types of outcomes or impacts does the FOA suggest this research could support?
The description indicates that this research approach is intended to improve causal inference, clarify biological pathways, and ultimately support better prevention strategies, risk assessment, or intervention targets related to prenatal and early developmental exposures.
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Applicants also applied for:
Applicants who have applied for this opportunity (RFA ES 17 005) also looked into and applied for these:
| Funding Opportunity |
|---|
| Environmental Health Sciences Core Centers (EHS CC) (P30) Apply for RFA ES 17 003 Funding Number: RFA ES 17 003 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| SBIR E-learning for HAZMAT and Emergency Response (R43/R44) Apply for RFA ES 17 004 Funding Number: RFA ES 17 004 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $100,000 |
| Exposure Analysis Services for the Environmental Influences on Child Health Outcomes (ECHO) Program (Admin Supp) Apply for PA 17 308 Funding Number: PA 17 308 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| Global Brain and Nervous System Disorders Research Across the Lifespan (R21) Apply for PAR 17 313 Funding Number: PAR 17 313 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $125,000 |
| Global Brain and Nervous System Disorders Research Across the Lifespan (R01) Apply for PAR 17 314 Funding Number: PAR 17 314 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| Novel Assays for Screening the Effects of Chemical Toxicants on Cell Differentiation (SBIR R44) Apply for RFA ES 17 007 Funding Number: RFA ES 17 007 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| Organotypic Culture Models developed from Experimental Animals for Chemical Toxicity Screening (R43) Apply for RFA ES 17 008 Funding Number: RFA ES 17 008 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| Population-Based Model Organism Research for G x E Exploration in Complex Disease Outcomes (R01 Clinical Trial Not Allowed) Apply for RFA ES 17 009 Funding Number: RFA ES 17 009 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $499,999 |
| Immuno-Oncology Translational Network (IOTN): Cancer Immunotherapy Research Projects (U01) Apply for RFA CA 17 045 Funding Number: RFA CA 17 045 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $500,000 |
| Outstanding New Environmental Scientist (ONES) Award (R01 Clinical Trial Optional) Apply for RFA ES 18 001 Funding Number: RFA ES 18 001 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| Environmental Health Sciences Core Centers (EHS CC) (P30 Clinical Trial Optional) Apply for RFA ES 18 003 Funding Number: RFA ES 18 003 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| Transition to Independent Environmental Health Research (TIEHR) Career Transition Award (K01 Clinical Trial Required) Apply for PAR 18 261 Funding Number: PAR 18 261 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| Transition to Independent Environmental Health Research (TIEHR) Career Transition Award (K01 Clinical Trial Not Allowed) Apply for PAR 18 291 Funding Number: PAR 18 291 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| The Role of the Microbiome in the Developmental Origins of Health and Disease (DOHaD) (R01 Clinical Trial Not Allowed) Apply for RFA ES 18 005 Funding Number: RFA ES 18 005 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $400,000 |
| Revolutionizing Innovative, Visionary Environmental health Research (RIVER) (R35 Clinical Trial Not Allowed) Apply for RFA ES 18 004 Funding Number: RFA ES 18 004 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $600,000 |
| SBIR E-learning for HAZMAT and Emergency Response (R43/R44 Clinical Trial Not Allowed) Apply for RFA ES 18 006 Funding Number: RFA ES 18 006 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $100,000 |
| Exposure Analysis Services for the Environmental Influences on Child Health Outcomes (ECHO) Program (Admin Supp - Clinical Trial Not Allowed) Apply for PA 18 783 Funding Number: PA 18 783 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| Novel Approaches for Characterizing Exposure and Response to Engineered Nanomaterials (R43 Clinical Trials Not Allowed) Apply for RFA ES 18 008 Funding Number: RFA ES 18 008 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| Chronic, Non-Communicable Diseases and Disorders Across the Lifespan: Fogarty International Research Training Award (NCD-LIFESPAN) (D43)(Clinical Trial Optional) Apply for PAR 18 901 Funding Number: PAR 18 901 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| Telomeres as Sentinels of Environmental Exposures, Psychosocial Stress, and Disease Susceptibility: A Methods Comparison Study (U01 Clinical Trial Optional) Apply for RFA AG 19 023 Funding Number: RFA AG 19 023 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $200,000 |
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