Opportunity Information: Apply for PA 16 445
The National Institutes of Health (NIH) grant opportunity titled "Trophoblast Differentiation and Function (R01)" (Funding Opportunity Number PA-16-445) is a discretionary research grant designed to stimulate strong, investigator-initiated research focused on how trophoblast cells develop and function during fertility and pregnancy. The central aim is to build fundamental, mechanistic knowledge about trophoblast differentiation and biology, including how the immune system influences or interacts with trophoblasts. NIH is emphasizing basic and translationally relevant discoveries that can clarify normal placental development and maternal-fetal interactions, with the expectation that these insights will ultimately accelerate the development of better diagnostics, preventions, and treatments for major placental-based pregnancy complications.
Scientifically, the FOA highlights trophoblast differentiation and function as a foundation for understanding both successful implantation and healthy placentation across gestation. Because trophoblasts are key drivers of embryo implantation, placental formation, and uterine remodeling, disruptions in their developmental programs can contribute to serious outcomes. The announcement explicitly connects this research area to clinically significant conditions including implantation failure, recurrent or frequent pregnancy loss, preeclampsia, fetal growth restriction, and preterm birth. By encouraging rigorous work on trophoblast lineage decisions, invasive behavior, endocrine functions, vascular interactions, and immune-mediated regulation, NIH is signaling interest in research that explains why these disorders occur and what biological pathways could be targeted to reduce risk or improve outcomes.
This opportunity uses the NIH R01 mechanism, which generally supports well-developed projects with clearly defined hypotheses, robust experimental plans, and meaningful potential impact on the field. The funding instrument type is a grant, and the activity category is listed under Health, Income Security and Social Services. The CFDA numbers associated with this program are 93.855, 93.856, and 93.865, indicating alignment with NIH programs in reproductive, maternal, and child health-related research portfolios. While the provided source data does not specify an award ceiling or the expected number of awards, the R01 structure typically allows budgets and project periods consistent with NIH R01 policies, with award size depending on scientific scope, institute priorities, and standard NIH review outcomes.
A notable feature of the FOA is its broad eligibility. In addition to common applicants such as public and private institutions of higher education, nonprofit organizations (including both 501(c)(3) and non-501(c)(3) entities), small businesses, for-profit organizations (other than small businesses), and various levels of government (state, county, city/township, special districts), the announcement explicitly includes a wide range of mission- and community-serving organizations. These include Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs). It also lists faith-based or community-based organizations, eligible federal agencies, regional organizations, U.S. territories or possessions, and tribal entities (both federally recognized tribal governments and Indian/Native American tribal organizations and governments that are not federally recognized). Importantly, non-domestic (non-U.S.) entities and foreign organizations are also included as eligible applicants, which opens the door for international research teams or cross-border collaborations where scientifically justified.
From an administrative standpoint, the NIH posted the opportunity with a creation date of September 23, 2016, and the original closing date shown in the source data is January 7, 2020. The focus of the announcement remains clear: encourage high-quality applications that push the science of trophoblast development and immune interaction forward, generating foundational knowledge that can be leveraged to address pregnancy disorders rooted in placental dysfunction.Apply for PA 16 445
- The National Institutes of Health in the health, income security and social services sector is offering a public funding opportunity titled "Trophoblast Differentiation and Function (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.855, 93.856, 93.865.
- This funding opportunity was created on 2016-09-23.
- Applicants must submit their applications by 2020-01-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
What is the name of this NIH funding opportunity?
The opportunity is titled "Trophoblast Differentiation and Function (R01)".
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is PA-16-445.
What type of funding mechanism is being used?
This opportunity uses the NIH R01 mechanism, which is generally intended for well-developed research projects with clearly defined hypotheses and robust experimental plans.
Is this considered a research grant?
Yes. It is a discretionary research grant intended to stimulate strong, investigator-initiated research.
What is the central scientific focus of the FOA?
The FOA focuses on how trophoblast cells develop and function during fertility and pregnancy, with an emphasis on building fundamental, mechanistic knowledge about trophoblast differentiation and biology.
Does the FOA include research on immune interactions with trophoblasts?
Yes. The announcement specifically includes interest in how the immune system influences or interacts with trophoblasts, as part of understanding maternal-fetal interactions and placental development.
What kinds of outcomes is NIH ultimately trying to influence through this research?
NIH is emphasizing basic and translationally relevant discoveries that clarify normal placental development and maternal-fetal interactions, with the expectation that insights from this work will ultimately help accelerate better diagnostics, prevention strategies, and treatments for major placental-based pregnancy complications.
Why are trophoblasts important in pregnancy research?
Trophoblasts are described as key drivers of embryo implantation, placental formation, and uterine remodeling. Because of these roles, disruptions in trophoblast developmental programs can contribute to serious pregnancy outcomes.
What pregnancy conditions are explicitly linked to this research area in the FOA?
The FOA explicitly connects trophoblast differentiation and function research to clinically significant conditions including implantation failure, recurrent or frequent pregnancy loss, preeclampsia, fetal growth restriction, and preterm birth.
What kinds of scientific topics does the FOA encourage within trophoblast biology?
Based on the description provided, the FOA encourages rigorous research that can address areas such as trophoblast lineage decisions, invasive behavior, endocrine functions, vascular interactions, and immune-mediated regulation.
Is the opportunity limited to basic research, or does it include translational relevance?
The FOA emphasizes basic and translationally relevant discoveries, especially where the resulting mechanistic understanding can clarify normal development and inform future clinical advances for placental-based disorders.
What is the funding instrument type?
The funding instrument type is a grant.
What activity category is listed for this opportunity?
The activity category is listed as Health, Income Security and Social Services.
What CFDA numbers are associated with this program?
The CFDA numbers listed are 93.855, 93.856, and 93.865.
Does the provided information specify an award ceiling or the expected number of awards?
No. The provided source data does not specify an award ceiling or the expected number of awards.
What does the description say about typical R01 budgets and project periods?
While no specific budget or project length is stated in the provided information, it notes that the R01 structure typically supports budgets and project periods consistent with NIH R01 policies, and that award size can depend on scientific scope, institute priorities, and standard NIH review outcomes.
Who is eligible to apply?
The FOA describes broad eligibility, including (among others): public and private institutions of higher education; nonprofit organizations (both 501(c)(3) and non-501(c)(3)); small businesses; for-profit organizations (other than small businesses); and multiple levels of government (state, county, city/township, and special districts).
Are minority-serving institutions explicitly included as eligible applicants?
Yes. The FOA explicitly includes several categories of minority-serving institutions, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs).
Are faith-based or community-based organizations eligible?
Yes. The eligibility list explicitly includes faith-based or community-based organizations.
Can government entities apply?
Yes. The FOA includes eligibility for various government entities, including state governments, county governments, city or township governments, and special district governments. It also lists eligible federal agencies.
Are U.S. territories or possessions eligible?
Yes. The FOA includes U.S. territories or possessions among eligible applicants.
Are tribal entities eligible?
Yes. The FOA includes tribal entities, including federally recognized tribal governments and Indian/Native American tribal organizations and governments that are not federally recognized.
Are non-U.S. (foreign) organizations eligible to apply?
Yes. The FOA explicitly states that non-domestic (non-U.S.) entities and foreign organizations are eligible applicants, supporting international teams or cross-border collaborations where scientifically justified.
When was this opportunity created (posted)?
The creation date provided is September 23, 2016.
What is the closing date shown in the provided source data?
The original closing date shown in the source data is January 7, 2020.
What is the overall purpose of the FOA in plain terms?
The FOA aims to encourage high-quality investigator-initiated research that advances the science of trophoblast development and immune interaction, generating foundational knowledge that can be leveraged to address pregnancy disorders rooted in placental dysfunction.
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